Articles from Io Therapeutics, Inc.

SPRING, Texas, March 11, 2026 (GLOBE NEWSWIRE) -- Io Therapeutics, Inc. in Spring, Texas, announces collaborative publication of data from preclinical studies with scientists at The University of Texas MD Anderson Cancer Center demonstrating effectiveness of the retinoid X receptor (RXR) agonist compound IRX4204 in models of prevention of estrogen receptor-negative and triple-negative breast cancers in three different genetically predisposed mouse models.

SPRING, Texas, Dec. 11, 2025 (GLOBE NEWSWIRE) -- Io Therapeutics, Inc., a privately held pharmaceutical company headquartered in Spring, Texas; announced today presentation at the San Antonio Breast Cancer Symposium, in San Antonio, TX; of data from preclinical studies demonstrating effectiveness of IRX4204, the company’s phase II clinical stage retinoid X nuclear receptor (RXR) agonist compound, for promoting killing of HER2+ breast cancer cells in combination with HER2-targeted chimeric antigen receptor modified T-cells (CAR-T). IRX4204 demonstrated synergistic killing with HER2-targeted CAR-T cells of human HER2+ breast cancer cells in vitro. The presentation by Drs. Martin E. Sanders, M.D., and Vidyasagar Vuligonda, Ph.D., is titled, “The RXR agonist IRX4204 promotes cytotoxicity of HER2+ breast cancer by HER2 targeted CAR-T cells.”

SPRING, Texas, Dec. 06, 2025 (GLOBE NEWSWIRE) -- Io Therapeutics, Inc., a privately held pharmaceutical company headquartered in Spring, Texas; announced today collaborative presentations at the 67th American Society of Hematology Annual Meeting and Exposition, in Orlando, Florida; with scientists from the Duke University School of Medicine in Durham, North Carolina; reporting data from preclinical studies in in vitro and xenograft mouse models demonstrating effectiveness of IRX4204, the company’s retinoid X nuclear receptor (RXR) agonist compound, against human multiple myeloma. IRX4204 had synergistic efficacy against human multiple myeloma in combination with anti-myeloma BCMA CAR-T cells and separately with a standard of care anti-myeloma drug lenalidomide.

HALIFAX, Nova Scotia and SPRING, Texas, Dec. 23, 2024 (GLOBE NEWSWIRE) -- Scientists at Dalhousie University in Halifax, and Io Therapeutics, Inc. in Spring Texas, announced today collaborative publication of data from studies demonstrating effectiveness of the RXR agonist compound IRX4204 in reversing demyelination, and functionally restoring movement in the paralyzed legs of mice subjected to an autoimmune-mediated demyelinating model of human multiple sclerosis (MS). The research report titled: “Selective retinoid X receptor agonism promotes functional recovery and myelin repair in experimental autoimmune encephalomyelitis”, G.D.S Kasheke, et al; was published in the December 21, 2024 edition of Acta Neuropathologica Communications.

The combination treatment resulted in increased numbers of anti-cancer tumor-infiltrating T-cells; decreased numbers of anti-cancer response inhibiting tumor-infiltrating myeloid derived suppressor cells; and substantial 84% inhibition of tumor growth

SPRING, Texas, Nov. 08, 2024 (GLOBE NEWSWIRE) -- Io Therapeutics, Inc., presented results from studies done in breast, colorectal, and prostate cancer models with the company’s newest anti-cancer compound IRX5010, an agonist of the retinoic acid nuclear receptor gamma, which was discovered in the company’s oncology drug program. The presentation titled “RAR Gamma Agonist Compounds Inhibit Tumor Growth, Promote Effector Memory Tumor Infiltrating T-cells, and Inhibit Tumor Infiltrating Myeloid Derived Suppressor Cells in Multiple Cancer Models” was delivered at The Society for Immunotherapy of Cancer (SITC) 39th Annual Meeting, being held in Houston, TX. The poster presentation was authored by Vidyasagar Vuligonda, Ph.D, Chief Scientific Officer of the company and inventor of the compound; and Martin E. Sanders, M.D., the company’s Chief Executive Officer.

SPRING, Texas, Sept. 18, 2024 (GLOBE NEWSWIRE) -- Io Therapeutics, Inc., presented results from studies done on the potential for prevention and treatment of normal aging-related neurodegeneration with its clinical stage experimental therapeutic RXR agonist compound IRX4204. The presentation titled “The highly potent and selective third generation RXR nuclear receptor agonist compound IRX4204 has potential for prevention and treatment of normal aging-related neurodegeneration” was presented at the FASEB Research Conference on Cellular and Molecular Mechanisms of Brain Aging, being held in Niagara Falls, NY, USA. The presentation was authored by Vidyasagar Vuligonda, Ph.D., Chief Science Officer, and Martin E. Sanders, M.D., Chief Executive Officer.

SPRING, Texas, July 16, 2024 (GLOBE NEWSWIRE) -- Io Therapeutics, Inc., presented today results from studies of IRX4204, the company’s phase II clinical development stage, highly selective RXR nuclear receptor agonist compound, supporting its potential use for treatment of amyotrophic lateral sclerosis (ALS).

SPRING, Texas, July 09, 2024 (GLOBE NEWSWIRE) -- Io Therapeutics, Inc., presented today results from studies done on the potential for prevention and treatment of normal aging-related neurodegeneration, Parkinson’s disease (PD), and Alzheimer’s disease (AD), with its clinical stage experimental therapeutic RXR nuclear receptor agonist compound IRX4204. IRX4204 is a highly potent and highly selective, orally available, brain penetrant, third generation RXR agonist compound which has been tested in early phase clinical trials in patients with Parkinson’s disease or cancers.   The presentation titled “The highly potent and selective RXR agonist compound IRX4204 is a potential treatment for normal aging-related neurodegeneration, Parkinson’s disease (PD), and Alzheimer’s disease (AD)” was delivered at the Federation of American Societies for Experimental Biology (FASEB) Seventh International Conference on Retinoids, being held in St. Paul, Minnesota, USA. The presentation was authored by Vidyasagar Vuligonda, Ph.D., Chief Science Officer of the company and inventor of IRX4204, and Martin E. Sanders, M.D., the company’s Chief Executive Officer.

SPRING, Texas, July 08, 2024 (GLOBE NEWSWIRE) -- Io Therapeutics, Inc., presented today results from studies done in breast, lung, colorectal, and prostate cancer models with the company’s newest anti-cancer compound IRX5010, an agonist of retinoic acid nuclear receptor gamma which was discovered in the company’s oncology drug program. The presentation titled “RAR Gamma Agonist Compounds Promote Effector Memory Tumor Infiltrating T-cells and are Effective in Multiple Cancer Models”, which was delivered at the Federation of American Societies for Experimental Biology (FASEB) Seventh International Conference on Retinoids, being held in St. Paul, Minnesota, USA; was authored by Vidyasagar Vuligonda, Ph.D., Chief Science Officer of the company and inventor of the compound; and Martin E. Sanders, M.D., the company’s Chief Executive Officer.

SPRING, Texas, Sept. 12, 2023 (GLOBE NEWSWIRE) -- Io Therapeutics, Inc., announced today the publication in Scientific Reports – Nature Publishing Group, of results from studies done with the company’s novel anti-cancer compound IRX4647, an agonist of the retinoic acid nuclear receptor gamma, discovered in the company’s oncology drug program. The paper, titled “A novel retinoic acid receptor-gamma agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment,” authored by Cheng-Hsin Wei, Ph.D., et al., reports studies done in the laboratory of the Molecular Pharmacology Program at the Frederick National Laboratory for Cancer Research (FNLCR), supervised by Xi Liu, Ph.D., Senior Principal Scientist; and Ethan Dmitrovsky, M.D., president of Leidos Biomedical Research and Director of the Frederick National Laboratory for Cancer Research.